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GOUT - A DISORDER OF PURINE NUCLEOTIDE METABOLISM

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Introduction Gout is a disorder of purine nucleotide metabolism. Cause joints to become red, tender and swollen. Also, may lead to kidney stones which cause kidney failure .Excessive production of uric acid leads to this condition (more than 7mg/dl). Further these uric acids get precipitated into mono sodium urate crystals which accumulate into joints and cause swelling and inflammation of joint. There are two types of gouts namely, primary gout and secondary gout. Primary Gout: Due to defect in purine nucleotide metabolism Secondary Gout:  Cancer, chemotherapy, psoriasis and renal dysfunction cause this condition.   Signs and Symptoms The most common signs of gout is inflammatory arthritis which is characterized by redness, tenderness and swelling of the affected joint. Usually, the first metatarso pharyngeal joint of great toe is affected (almost in 90% of the cases). As the uric acid levels rise the uric acid gets precipitated and form tophi which gets accumulated in joints...
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IMMUNITY - INNATE OR ACQUIRED?

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  Introduction Immunity is the ability of body to resist infection (invasion) caused by foreign agents and to neutralize their effects on body. What brings about immunity? Lymphocytes are the cells which bring about the immunity to the body. On the basis of presence or absence of granulocytes, the WBC’s are classified into two categories: Granulocytes & Agranulocytes. Granulocytes: Consists of 3 types of different cells, namely Eosinophils, Basophils & Neutrophils. Agranulocytes: Consists of 2 types of cells called, Lymphocytes (B and T Lymphocytes) & Monocytes. The cell which is responsible for immune response is the part of the agranulocyte WBC. Different types of Immunities Innate and acquired are the two types of immunity responsible for the immune system of the human body. However, acquired immunity is divided further into cellular and humoral immunity. Innate Immunity: The immunity gain by an individual before birth genetically is called innate ...
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MULTIPLE MYELOMA – A PLASMA CELL MYELOMA or MYELOMATOSIS

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History of Multiple Myeloma Multiple Myeloma is a cancer of plasma cells which are present in blood, has been present since centuries. The first documented case of this disease was issued less than 160 year from today’s date. The first patient of this disease Thomas Alexander McBean excreted a certain type of protein, which was studied by Henry Bence Jones. These proteins were further named as "Bence Jones Proteins". The first diagnosis of multiple myeloma was viable when ROENTGEN’S rays were discovered. What are the other names of Multiple Myeloma   ? PLASMA CELL MYELOMA   , MYELOMATOSIS, KAHLER’S DISEASE, MYELOMA Cause The cause of Multiple Myeloma is unknown. Several efforts are going on by scientists all around the globe to know the main cause of multiple myeloma. Risk Factors  Monoclonal Gammopathy increases the risk of person developing myeloma; obesity is also one of the risk factor in developing myeloma. Diagnosis Several diagnostic met...
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